Future-proofing LN2 Cryogenic Storage at the Rayne Institute

A major project to modernise cryogenic infrastructure

The Rayne Institute at King’s College London is home to leading clinical and laboratory research groups specialising in haematology and advanced therapies. Multiple departments, including the Department of Haematology, the Haematology Biobank and the Gene Therapy Vector Facility (GTVF), rely on secure, long-term cryogenic storage to preserve thousands of valuable biological samples.

When the institute’s existing liquid nitrogen (LN2) storage infrastructure began to show signs of ageing, a major upgrade project was launched. The goal was to modernise the facility, improve safety, increase storage capacity and reduce LN2 consumption, while ensuring ongoing protection of critical samples.

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The Challenge

The original cryogenic facility had been in continuous use for over a decade and was approaching the end of its operational life. At the same time, demand for storage capacity was increasing across research and clinical teams.

The Rayne Institute required a solution that could:

Replace ageing cryogenic equipment with modern infrastructure
Expand LN2 sample storage capacity
Ensure reliable LN2 supply with automated filling across multiple tanks
Improve ventilation and oxygen monitoring for enhanced safetyReduce LN2 consumption across the facility
Integrate new systems with existing third-party equipment
Provide secure temporary storage during installation to protect valuable samples

The Solution

Haier Biomedical worked closely with the Rayne Institute to design and deliver a complete upgrade of the cryogenic storage facility. The project extended beyond replacing storage tanks to include a full infrastructure redesign.

The upgraded solution included new cryogenic storage units, improved ventilation systems, enhanced oxygen monitoring, and an automated LN2 delivery system. Careful planning ensured that new equipment could operate alongside existing systems, creating a fully integrated environment.

A key priority was maintaining sample integrity throughout the installation. Thousands of samples were safely managed through temporary storage solutions, including on-site relocation, external storage containers and transfers to licensed facilities. This ensured uninterrupted protection of critical materials.

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The Result

The upgraded facility now provides a modern, efficient and reliable cryogenic storage environment that supports the institute’s ongoing research and clinical programmes.

Key outcomes include:
A fully modernised LN2 cryogenic storage infrastructure
Expanded storage capacity to support future growth
Improved safety through enhanced ventilation and elimination of nuisance alarms
Seamless integration with existing cryogenic equipment
Secure handling and protection of samples throughout the upgrade process
Up to 50 percent reduction in LN2 consumption compared to the previous system

The new system has also significantly improved operational efficiency. LN2 usage has been reduced from approximately 2,200 litres per week to well below the targeted 1,200 to 1,500 litres, delivering both cost and sustainability benefits.

Conclusion

By upgrading its cryogenic storage infrastructure, the Rayne Institute has secured a future-ready facility capable of supporting advanced research in haematology, biobanking and cell and gene therapy.

The project demonstrates how a carefully planned and expertly delivered solution can enhance safety, improve efficiency and create capacity for growth, while ensuring the protection of valuable biological samples at every stage.